Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3078 | 3078-30527 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82AS, L90M | V11VI, F53L, Q58E | L10I, I15V, K20MR, E35ED, M36I, N37T, L38LW, R41K, K55R, D60E, Q61DEKN, I62V, L63P, I64V, A71IT, I85V, I93L |
| >3078-30527| codons 1-99 PQITLWQRPIITIKVGGQLREALLDTGADDTVLEDITWPGKWKPKLIGGIGGLVRVREYE NVPVEICGHKTIGTVLVGPTPSNIVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75T, M184V, L210W, T215Y | K219N | L100I, K103N | V35M, V118I, D121Y, K122E, I135IV, R211K, E248N, L283I, I293V, E297K, R356K, G359S, A371V, I375V, V381I, K390R |
| >3078-30527| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKEGKISKIGPENPYNTPV FAIKKKNSDKWRKLTDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL YEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPNKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEVVQKVATESIIIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |