Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3076 | 3076-30318 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V | L10F, L24I, L33F, K43T | Q61H, L63P, A71I, I72T, V77I, T91TA, Q92K |
| >3076-30318| codons 1-99 PQITLWQRPFVTIKIGGQLKEALIDTGADDTVFEEMNLPGRWTPKLIGGIGGFVKVRQYD HIPIEICGHKITGTVLIGPTPANVIGRNLLAKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219R | K20R, V35M, K43N, E44D, V118I, K122E, H208Y, R211K, D218E, V245E, E248Q, A272P, K277R, T286TA, I293V, V317A, I326V, Q334E, F346Y, G359GS, V365I, E370D, A371V, I375V, T377L, K390R, K395R, A400S |
| >3076-30318| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTELENDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPERKHQKEPPFLWMGYELHPDKWT VQPIELPQKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTEEAE LELAENREILKEPVHGAYYDPSKDLVAEIQKQGEGQWTYQIYQEPYKNLKTGKYARMRSA HTNDIKQLTDVVQKVALESIVIWGKTPKFRLPIQRETWES |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |