Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3075 | 3075-30311 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, T215F | V75T, K219Q, N348I | K103N | E6EK, K20R, V35L, K122E, S162C, T200TA, Q207E, H208Y, R211K, D218E, A272P, K277R, D324E, Q334L, M357MT, A360AT, A376S, K390R |
| >3075-30311| codons 1-400 PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELREYLLKWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGLGQWTYQIYQEPFKILKTGKYARTRGT HTNDVKQLTEAVQKISTESIVIWGKTPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46IL, I54V, I84V, L90M | L10F, L33F, G73S | G16GA, E34Q, N37ND, R57K, L63P, I66IV, A71V, I72K, T91TS, I93L, C95F | G94GD |
| >3075-30311| codons 1-99 PQITLWQRPFVTIKIAGQLKEALLDTGADDTVFQEMDLPGRWKPKLIGGIGGFVKVKQYD QIPIEVCGHKVKSTVLVGPTPVNVIGRNLMSQLDFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |