<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3075 3075-30311 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46IL, I54V, I84V, L90M L10F, L33F, G73S G16GA, E34Q, N37ND, R57K, L63P, I66IV, A71V, I72K, T91TS, I93L, C95F G94GD
>3075-30311| codons 1-99
PQITLWQRPFVTIKIAGQLKEALLDTGADDTVFQEMDLPGRWKPKLIGGIGGFVKVKQYD
QIPIEVCGHKVKSTVLVGPTPVNVIGRNLMSQLDFTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, M184V, T215F V75T, K219Q, N348I K103N   E6EK, K20R, V35L, K122E, S162C, T200TA, Q207E, H208Y, R211K, D218E, A272P, K277R, D324E, Q334L, M357MT, A360AT, A376S, K390R  
>3075-30311| codons 1-400
PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRAKIEELREYLLKWGFFTPEQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGLGQWTYQIYQEPFKILKTGKYARTRGT
HTNDVKQLTEAVQKISTESIVIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006