Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3074 | 3074-30411 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184MV, L210W, T215Y | K101E, Y181C, G190GA | A98G | E28EK, V35L, T39A, E44D, R83RK, V118I, K122E, Q174QR, D177E, G196E, E203EK, Q207E, K223KE, T286A, E297K, A304AE, P313T, V317A, D324E, G359S, A371V, I375V, A376S |
| >3074-30411| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALLEICAELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKKTQDFWEVQLGIPHPGGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPEIVI CQYVDDLYVASDLEIEQHRTKIKELREHLWRWGFYTPDKKHQEEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTKEAE LELEENREILKETVHGAYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKVSTESIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, I84V, L90M | V32I_RR, L33F, G73S, L89V | L10V, V11L, I13V, L19V, K20R, M36L, R57K, L63P, A71V |
| >3074-30411| codons 1-99 PQITLWQRPVLTVKIGGQVREALLDTGADDTIFEELNLPGRWKPKIIGGIGGFVKVKQYD QIPIEICGHKVISTVLVGPTPTNVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |