<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3074 3074-30411 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184MV, L210W, T215Y   K101E, Y181C, G190GA A98G E28EK, V35L, T39A, E44D, R83RK, V118I, K122E, Q174QR, D177E, G196E, E203EK, Q207E, K223KE, T286A, E297K, A304AE, P313T, V317A, D324E, G359S, A371V, I375V, A376S  
>3074-30411| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALLEICAELEKDGKISKIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKKTQDFWEVQLGIPHPGGLEKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPEIVI
CQYVDDLYVASDLEIEQHRTKIKELREHLWRWGFYTPDKKHQEEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTKEAE
LELEENREILKETVHGAYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEVVQKVSTESIVIWGKTPKFKLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82T, I84V, L90M V32I_RR, L33F, G73S, L89V L10V, V11L, I13V, L19V, K20R, M36L, R57K, L63P, A71V  
>3074-30411| codons 1-99
PQITLWQRPVLTVKIGGQVREALLDTGADDTIFEELNLPGRWKPKIIGGIGGFVKVKQYD
QIPIEICGHKVISTVLVGPTPTNVIGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006