<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3073 3073-30408 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54V, V82S L24I, K43T L10I, L19I, K20R, E35D, M36I, N37D, I62V, L63P, T74S  
>3073-30408| codons 1-99
PQITLWQRPIVTIKIGGQIREALIDTGADDTVLEDIDLPGRWTPKMIVGIGGFVKVRQYD
QVPIEICGHKAIGSVLVGPTPSNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, K70R, Y115YF, Q151M, M184V A62V, V75I, F116Y K103N, V106VM, G190GA   P4S, T7TP, K11KR, V35I, S68G, T69A, V118I, D123DE, S162C, G196E, E203D, F214L, T286A, E297A, I341IV, F346Y, M357T, T386I, K390R, E399D  
>3073-30408| codons 1-399
PISSIEPVPVRLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV
FVIKRKDGARWRKLIDFRELNKRTQDFWEVQLGIPHPAGLKKNKSMTVLDVGDAFYSIPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQCSMTKILEPFRKQNPDIVI
YQYVDDLYVASDLEIEQHRTKIDELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQVYQEPYKNLKTGKYARTRGA
HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006