Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3072 | 3072-30326 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82S, L90M | L23I, Q58E | L10I, I15V, K20R, M36I, N37D, I62V, L63P | G52GV |
| >3072-30326| codons 1-99 PQITLWQRPIVTIKVGGQLREAILDTGADDTVLEEIDLPGRWKPKMIVGIGVFVKVREYD QVPIEICGHKAIGTVLVGPTPSNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, K70R, M184V, T215F | K219Q | P4S, K20R, V118I, I135T, F214L, K223KQ, L228H, T240TK, V245E, A272P, V276I, L283I, T286TP, I293V, P294T, R356RK, M357T, G359GS, A376V, T386M, K395KR | G18GS |
| >3072-30326| codons 1-400 PISSIETVPVKLKPGMDSPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLFTPDQKHQQEPPFHWMGYELHPDKWK VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKIKQLCKLIRGPKALTEVVTLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKTRSA HTNDVKQLTEAVQKIVTESIVIWGKMPKFKLPIQRETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |