Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3069 | 3069-30319 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I50V, I54A, V82A | L33F | L10IV, I13V, N37S, R41RK, I62V, L63P, I72V, V77I, I93L |
| >3069-30319| codons 1-99 PQITLWQRPVVTVKIGGQLKEALLDTGADDTVFEEMSLPGKWKPKMIVGVGGFAKVRQYD QVPIEICGHKAVGTVLIGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, L210W, T215Y | K219E | F227L | V35M, E44D, S68SG, V118I, K122E, A158S, G196E, T200KR, I202V, Q207D, R211K, L283I, I293V, E297K, I329V, T338S, M357V, G359S, A371V, I382IV, K390R |
| >3069-30319| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKDGKISKIGPENPYNTPV FAIKKKNGTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRRKVEELRDHLWKWGFYTPDEKHQKEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQGQWSYQIYQEPFKNLKTGKYARVRSA HTNDVKQLTEVVQKIATESIVVWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |