<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3069 3069-30319 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I50V, I54A, V82A L33F L10IV, I13V, N37S, R41RK, I62V, L63P, I72V, V77I, I93L  
>3069-30319| codons 1-99
PQITLWQRPVVTVKIGGQLKEALLDTGADDTVFEEMSLPGKWKPKMIVGVGGFAKVRQYD
QVPIEICGHKAVGTVLIGPTPANIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, L210W, T215Y K219E   F227L V35M, E44D, S68SG, V118I, K122E, A158S, G196E, T200KR, I202V, Q207D, R211K, L283I, I293V, E297K, I329V, T338S, M357V, G359S, A371V, I382IV, K390R  
>3069-30319| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKDGKISKIGPENPYNTPV
FAIKKKNGTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIEQHRRKVEELRDHLWKWGFYTPDEKHQKEPPLLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQGQWSYQIYQEPFKNLKTGKYARVRSA
HTNDVKQLTEVVQKIATESIVVWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006