Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3065 | 3065-30519 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54V, V82A | L24I, L33F | L10I, T12P, K14R, N37D, F53FY, I62V, L63P, G68D, A71T, I72V, V77I |
| >3065-30519| codons 1-99 PQITLWQRPIVPIRIGGQLKEALIDTGADDTVFEEMDLPGRWKPKLIVGIGGYVKVRQYD QVPIEICDHKTVGTVLIGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, T215Y | K101P, K103KN | K43N, A98S, V118I, K122E, I135T, Q207E, R211K, V245M, A272P, I293V, D324E, Q334N, P345Q, G359GS, S379SC, K390R, E399D |
| >3065-30519| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLPKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGNGQWTYQIYQEQFKNLKTGKYARMRSA HTNDVKQLTEAVQKIATECIVIWGKTPKFRLPIQKETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |