Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3061 | 3061-30512 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82VA, L90M | L10FI, G73S, L89V | I13V, K20R, E35D, M36I, N37D, L63P, H69Y, K70KE, A71IV, I93L |
| >3061-30512| codons 1-99 PQITLWQRPIVTVKIGGQLREALLDTGADDTILEDIDLPGRWKPKIVGGIGGFMKVRQYD QIPIEICGYEVISTVLVGPTPANIIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, V75T, M184V, L210W, T215Y | D67G, K219D | K101E, Y181C, G190A | V35I, E40F, K43E, I47IF, S68G, W88C, V118I, K122E, K166R, I195K, G196E, T200V, E203K, R211H, K223E, A272P, T286A, E297EA, V317A, I326V, I329V, Q334L, F346Y, K350R, R358K, G359S, V365I, A371V, E399D | K30KR |
| >3061-30512| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEERIKALIEICTFLEEEGKFSKIGPENPYNTPV FAIKKKGGTKWRKITDFRELNKRTQDFCEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI CQYVDDLYVASDLEKEQHRVKIKELRQHLWHWGFYTPDDKHQEEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTAEAE LELAENREILKEPVHGAYYDPSKDLVAEVQKQGLGQWTYQIYQEPYKNLRTGKYARMKSA HTNDIKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |