Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3060 | 3060-30402 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82A, L90M | L10F, L33F, Q58E | T4S, I13V, G16A, D60DE, I62IV, L63P, V77I, L89IM |
| >3060-30402| codons 1-99 PQISLWQRPFVTVKIAGQLKEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGFVKVREYE QVPIEICGHKAIGTVVIGPTPANIIGRNMMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75VIM, L210W, T215Y | K101E, Y181YC, G190GC | A98G | K43Q, V60I, V118I, K122KE, I135T, S162A, Q207E, R211K, L228R, A272P, T286A, V292VI, E297K, D324E, M357T, R358K, G359S, K366R, K390R, K395R, E396D, E399D, A400AT |
| >3060-30402| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPI FAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI CQYMDDLYVCSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEIIPLTKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTKSA HTNDVRQLTEAVQKIATESIVIWGKTPKFRLPIQRDTWDT |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |