<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3060 3060-30402 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, V82A, L90M L10F, L33F, Q58E T4S, I13V, G16A, D60DE, I62IV, L63P, V77I, L89IM  
>3060-30402| codons 1-99
PQISLWQRPFVTVKIAGQLKEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGFVKVREYE
QVPIEICGHKAIGTVVIGPTPANIIGRNMMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, V75VIM, L210W, T215Y   K101E, Y181YC, G190GC A98G K43Q, V60I, V118I, K122KE, I135T, S162A, Q207E, R211K, L228R, A272P, T286A, V292VI, E297K, D324E, M357T, R358K, G359S, K366R, K390R, K395R, E396D, E399D, A400AT  
>3060-30402| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPI
FAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI
CQYMDDLYVCSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEIIPLTKEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTKSA
HTNDVRQLTEAVQKIATESIVIWGKTPKFRLPIQRDTWDT

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006