Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3059 | 3059-30401 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215Y | L100I, K103N | A98G | P4PS, E6K, V35I, T39A, E44D, V118I, K122P, D123E, I135V, E203KQ, H208Y, R211D, K223Q, A272P, K281R, L283I, I293V, E297R, P313S, S322T, Q334D, G335S, M357T, G359S, A371V, A376T, T386A, K390R | P170PCRS |
| >3059-30401| codons 1-399 PISSIKTVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPGGIKKNKSVTVLDVGDAYFSIPL DPEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILESFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIQELRQYLWDWGFYTPDKKHQQEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLIRGTKALTEVVPLTREAE LELAENREILKESVHGVYYDPTKDLIAEIQKQGDSQWTYQIYQEPFKNLKTGKYARTRSA HTNDVKQLTEVVQKITTESIVIWGKAPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, V82A, I84V | V11I, L24I, L33F | L10I, I13V, K20R, E35D, M36I, N37E, I62V, L63PT, E65ED, T74S, I85IV, L89M |
| >3059-30401| codons 1-99 PQITLWQRPIITVKIGGQLREALIDTGADDTVFEDIELPGRWKPKLIGGIGGFIKVRQYD QVTIDICGHKAIGSVLVGPTPANVVGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |