<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3059 3059-30401 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, V82A, I84V V11I, L24I, L33F L10I, I13V, K20R, E35D, M36I, N37E, I62V, L63PT, E65ED, T74S, I85IV, L89M  
>3059-30401| codons 1-99
PQITLWQRPIITVKIGGQLREALIDTGADDTVFEDIELPGRWKPKLIGGIGGFIKVRQYD
QVTIDICGHKAIGSVLVGPTPANVVGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74V, M184V, L210W, T215Y   L100I, K103N A98G P4PS, E6K, V35I, T39A, E44D, V118I, K122P, D123E, I135V, E203KQ, H208Y, R211D, K223Q, A272P, K281R, L283I, I293V, E297R, P313S, S322T, Q334D, G335S, M357T, G359S, A371V, A376T, T386A, K390R P170PCRS
>3059-30401| codons 1-399
PISSIKTVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKDGKISKIGPENPYNTPV
FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPGGIKKNKSVTVLDVGDAYFSIPL
DPEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILESFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIQELRQYLWDWGFYTPDKKHQQEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLIRGTKALTEVVPLTREAE
LELAENREILKESVHGVYYDPTKDLIAEIQKQGDSQWTYQIYQEPFKNLKTGKYARTRSA
HTNDVKQLTEVVQKITTESIVIWGKAPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006