<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3058 3058-30401 France 2003 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54L, V82A, L90M L33F, K43KT L10I, L19I, K20R, E35D, M36I, N37D, R41K, I62V, L63P, H69K, T74S, L89M, I93L  
>3058-30401| codons 1-99
PQITLWQRPIVTIKIGGQIREALLDTGADDTVFEDIDLPGKWTPKMIGGIGGFLKVRQYD
QVPIEICGKKAIGSVLVGPTPANIIGRNMMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T215Y       P4PS, V21VI, V35T, T39E, E44D, S48T, K122E, D123N, K173T, D177E, T200A, Q207E, L210LS, R211K, D218DE, P243Q, V245Q, A272S, E291D, I293V, Q334N, G335D, R356K, G359T, K366R, A371V, T377V, K390R  
>3058-30401| codons 1-399
PISSIETVPVKLKPGMDGPKIKQWPLTEEKIKALTEICEELEKDGKITKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTQNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLSKWGFYTPEKKHQKEPPFLWMGYELHPDKWT
VQQIQLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKALTDVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNDQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVRQLTEVVQKIAVESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006