Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3058 | 3058-30401 | France | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, V82A, L90M | L33F, K43KT | L10I, L19I, K20R, E35D, M36I, N37D, R41K, I62V, L63P, H69K, T74S, L89M, I93L |
| >3058-30401| codons 1-99 PQITLWQRPIVTIKIGGQIREALLDTGADDTVFEDIDLPGKWTPKMIGGIGGFLKVRQYD QVPIEICGKKAIGSVLVGPTPANIIGRNMMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T215Y | P4PS, V21VI, V35T, T39E, E44D, S48T, K122E, D123N, K173T, D177E, T200A, Q207E, L210LS, R211K, D218DE, P243Q, V245Q, A272S, E291D, I293V, Q334N, G335D, R356K, G359T, K366R, A371V, T377V, K390R |
| >3058-30401| codons 1-399 PISSIETVPVKLKPGMDGPKIKQWPLTEEKIKALTEICEELEKDGKITKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTQNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLSKWGFYTPEKKHQKEPPFLWMGYELHPDKWT VQQIQLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKALTDVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNDQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVRQLTEVVQKIAVESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |