<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3057 3057-30325 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, L74V, M184V, T215F K219Q L100LI, K103N   T69N, I94IL, K122E, D123DG, V179I, I202V, D218E, R284K, A288S, I293V, Q334N, G335S, M357T, A360AT, V365I, V372VL, K390R, E396ED  
>3057-30325| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSNRWRKVVDFRELNKRTQDFWEVQLGLPHPAGIKKNKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII
YQYVDDLYVGSDLEIGQHRTKVEELRQHLLRWGFFTPEQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGTKSLTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNSQWTYQIYQEPFKNLKTGKYARTRGT
HTNDIKQLTEALQKIATESIVIWGKTPKFRLPIQKDTWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54M, L90M L33F, Q58E, G73C L10I, V11L, I13V, K14KR, K20T, K55R, R57K, Q61E, I62V, L63E, A71T, I72T, V77I, V82I  
>3057-30325| codons 1-99
PQITLWQRPILTVRIGGQLTEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGFMRVKEYD
EVEIEICGHKTTCTVLIGPTPINIIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006