Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3057 | 3057-30325 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74V, M184V, T215F | K219Q | L100LI, K103N | T69N, I94IL, K122E, D123DG, V179I, I202V, D218E, R284K, A288S, I293V, Q334N, G335S, M357T, A360AT, V365I, V372VL, K390R, E396ED |
| >3057-30325| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKVVDFRELNKRTQDFWEVQLGLPHPAGIKKNKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIGQHRTKVEELRQHLLRWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGTKSLTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNSQWTYQIYQEPFKNLKTGKYARTRGT HTNDIKQLTEALQKIATESIVIWGKTPKFRLPIQKDTWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, L90M | L33F, Q58E, G73C | L10I, V11L, I13V, K14KR, K20T, K55R, R57K, Q61E, I62V, L63E, A71T, I72T, V77I, V82I |
| >3057-30325| codons 1-99 PQITLWQRPILTVRIGGQLTEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGFMRVKEYD EVEIEICGHKTTCTVLIGPTPINIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |