Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3056 | 3056-30318 | France | 2003 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82T | L10F, L89V | I13V, K20M, M36I, R41K, I62V, L63P, A71V, I72V, I93L |
| >3056-30318| codons 1-99 PQITLWQRPFVTVKIGGQLMEALLDTGADDTVLEEINLPGKWKPKIIGGIGGFVKVRQYD QVPIEICGHKVVGTVVVGPTPTNIIGRNVLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K101KE | K32R, V35T, T39K, K43E, V60I, V118I, D121Y, K122E, I135IV, E138A, S162A, D177E, I178M, E204EK, Q207E, V241I, V245Q, D250E, A272P, K277R, T286A, G333E, R358K, G359S, A371V, T377Q, S379C, K390R |
| >3056-30318| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIRALTEICKELEEEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL YEDFRKYTAFTIPSVNNATPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPEMVI YQYVDDLYVGSDLEIGQHRTKIEKLREHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT IQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYARMKSA HTNDVKQLTEVVQKIAQECIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |