Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3055 | 3055-40212 | France | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 43 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, L90M | L89V | L10I, T12A, I13V, K20T, L33V, M36I, R41K, L63P, A71T | R8Q |
| >3055-40212| codons 1-99 PQITLWQQPIVAVKIGGQLTEALLDTGADDTIVEEINLPGKWKPKIVGGIGGFIKVRQYD QIPIEICGHKTIGTVLVGPTPVNIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219R | K103N | A98G, V108I | K20R, V35I, K43E, E44D, W88C, V118I, D123E, I135M, D177E, G196E, E203K, Q207E, H208Y, R211K, K223Q, V245E, I293V, E297K, V317A, I329V, G359S, T386I, Q394T | N54I |
| >3055-40212| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEEDGKISKIGPEIPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFCEVQLGIPHPGGLKKNKSVTILDVGDAYFSIPL DKEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIEQHRTKIKELREYLWKWGFYTPDRKHQQEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGAYYDPSKDLIAEVQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPITKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |