<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3054 3054-30414 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, V82A L24I L10I, T12P, K14KR, K20R, E35D, M36I, R41K, K55KR, R57K, L63P, I64V, H69R, A71V, I93L  
>3054-30414| codons 1-99
PQITLWQRPIVPIRIGGQLREALIDTGADDTVLEDINLPGKWKPKIIGGIGGFVRVKQYD
QIPVEICGRKVIGTVVVGPTPANIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184V, L210W, T215Y D67G, K219N K103H, Y181C, G190A   S3SC, V35L, T39A, K49R, S68G, V90I, K122E, I135T, S162D, Q174H, A272P, I329L, G335D, M357T, G359S, T369A, E399D  
>3054-30414| codons 1-399
PICPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICAELEKEGKISRIGPENPYNTPV
FAIKKKGGTKWRKVVDFRELNKRTQDFWEIQLGIPHPAGLKKHKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKHNPDIVI
CQYVDDLYVASDLEIGQHRTKIEELRQHLWRWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQGQDQWTYQIYQEPFKNLKTGKYARTRSA
HTNDVKQLAEAVQKIATESIVIWGKTPKFKLPIQKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006