Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3052 | 3052-30326 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V, T215F | D67G, K219E | V35VI, S68G, K101Q, K122E, D123E, S162Y, V179VI, T200A, L228H, V245L, A272P, K277R, L283I, R284K, I293V, E297A, I326IV, I329IV, M357MI, R358K, A360T, T377R |
| >3052-30326| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKGGTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIGQHRAKIEELRQHLLRWGFFTPDEKHQKEPPFHWMGYELHPDKWT VQPILLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIKGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLVAEVQKQGQGQWTYQIYQEPFKNLKTGKYARIKGT HTNDVKQLTEAVQKIARESIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, I84V, L90M | G73GS, L89V | L10LI, I13IV, K14R, L19LP, K20I, D60E, L63P, A71V, I93L |
| >3052-30326| codons 1-99 PQITLWQRPIVTVRIGGQPIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFMKVRQYE QIPIEICGHKVISTVLVGPTPVNVIGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |