Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3051 | 3051-30326 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74I, M184V | K219Q | K103N | K43KE, V60VI, K122P, K173R, Q174K, D177E, V179I, Q207R, L210LM, R211S, F214L, A272P, K277R, R284K, T286A, E297R, V317A, Q334L, M357T, V365I, A376T, E399D |
| >3051-30326| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEEEGKISKIGPENPYNTPI FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRKNPEIII YQYVDDLYVGSDLEIGQHRTKIEELRRHLMSWGLTTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLKGAKALTEVIPLTREAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARTRGA HTNDIKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | K43T | L10I, K20R, E35D, M36I, N37E, R41K, R57RK, I62V, L63S, I64IM, A71V, I72IT, V77I, I93L |
| >3051-30326| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIELPGKWTPKLIGGIGGFVKVKQYD QVSMEICGHKVTGTVLIGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |