<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3050 3050-30326 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74V, M184V, T215F K219Q Y181C, G190S   K20KR, T27TS, V35T, V60I, K101Q, K122E, I135V, S162Y, V179VI, E203D, H208Y, R211K, K223Q, E224D, L228H, A272P, K277R, L283I, I293V, D324E, I326L, Q334P, R358RK, G359S, K366R, T369V, E370Q, A371V, I375V, K390R  
>3050-30326| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLSEEKIKALTEICTELEKEGKISKIGPENPYNTPI
FAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIII
CQYVDDLYVSSDLEIGQHRTKIDELRQYLLKWGFFTPDQKHQQDPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKELLAEIQKQGPGQWTYQIYQEPFKNLKTGKYARMKSA
HTNDVRQLVQVVQKVATESIVIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54M, V82A, L90M L10F, L33F, L89V G16A, L19E, K20R, M36I, I62V, L63P, C67Y, A71IV  
>3050-30326| codons 1-99
PQITLWQRPFVTIKIAGQEREALLDTGADDTIFEEINLPGRWKPKIVGGIGGFMKVRQYD
QVPIEIYGHKVIGTVLVGPTPANIIGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006