Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3050 | 3050-30326 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82A, L90M | L10F, L33F, L89V | G16A, L19E, K20R, M36I, I62V, L63P, C67Y, A71IV |
| >3050-30326| codons 1-99 PQITLWQRPFVTIKIAGQEREALLDTGADDTIFEEINLPGRWKPKIVGGIGGFMKVRQYD QVPIEIYGHKVIGTVLVGPTPANIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, M184V, T215F | K219Q | Y181C, G190S | K20KR, T27TS, V35T, V60I, K101Q, K122E, I135V, S162Y, V179VI, E203D, H208Y, R211K, K223Q, E224D, L228H, A272P, K277R, L283I, I293V, D324E, I326L, Q334P, R358RK, G359S, K366R, T369V, E370Q, A371V, I375V, K390R |
| >3050-30326| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLSEEKIKALTEICTELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIII CQYVDDLYVSSDLEIGQHRTKIDELRQYLLKWGFFTPDQKHQQDPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKELLAEIQKQGPGQWTYQIYQEPFKNLKTGKYARMKSA HTNDVRQLVQVVQKVATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |