Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3048 | 3048-30319 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90LIM | T12TPS, I13IV, K14KR, L19LI, L33V, M36MI, N37ND, I62IV, L63P, A71AT, I72V |
| >3048-30319| codons 1-99 PQITLWQRPLVSVRIGGQIKEALLDTGADDTVVEEIDLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTVGTVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K49R, R83RK, I135T, S162C, V189VI, T200A, D250DG, T286A, K311R, P321PS, G359GS, A376T, T386A |
| >3048-30319| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYIGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKGSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTEEAE LELAENREILREPVHGVYYDSSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEAVQKITTESIVIWGKAPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |