<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3045 3045-30317 France 2003 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54S, V82A L33F, Q58E, N83D L10V, I13V, K14R, I15V, M36L, R41RK, D60DE, I62IV, L63P, H69K, I85V, L89I, T91TS  
>3045-30317| codons 1-99
PQITLWQRPVVTVRVGGQLKEALLDTGADDTVFEELNLPGKWKPKMIVGIGGFSKVREYE
QVPIEICGKKAIGTVLVGPTPADIVGRNILSQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, L74V, Y115F, M184V, T215F K219Q Y181C, G190A   T7A, K11T, K20KR, V35T, T39R, K43E, K101Q, D121H, K122E, D123S, I135T, K173S, Q174K, N175Y, D177E, G196E, Q207A, V245Q, T286A, E291D, K311R, M357K, R358K, G359S, K366R, T369V, E370D, A371V, I375V, A376I, T386I  
>3045-30317| codons 1-400
PISPIEAVPVTLKPGMDGPRVKQWPLTEEKIKALTEICREMEEEGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAFFSVPL
HESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSKYPEIVI
CQYVDDLYVASDLEIEQHRTKIEELRAHLLRWGFFTPDQKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDVIPLTEEAE
LELAENREILREPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARKKSA
HTNDVRQLVDVVQKVITESIVIWGKIPKFKLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006