Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3045 | 3045-30317 | France | 2003 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54S, V82A | L33F, Q58E, N83D | L10V, I13V, K14R, I15V, M36L, R41RK, D60DE, I62IV, L63P, H69K, I85V, L89I, T91TS |
| >3045-30317| codons 1-99 PQITLWQRPVVTVRVGGQLKEALLDTGADDTVFEELNLPGKWKPKMIVGIGGFSKVREYE QVPIEICGKKAIGTVLVGPTPADIVGRNILSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, L74V, Y115F, M184V, T215F | K219Q | Y181C, G190A | T7A, K11T, K20KR, V35T, T39R, K43E, K101Q, D121H, K122E, D123S, I135T, K173S, Q174K, N175Y, D177E, G196E, Q207A, V245Q, T286A, E291D, K311R, M357K, R358K, G359S, K366R, T369V, E370D, A371V, I375V, A376I, T386I |
| >3045-30317| codons 1-400 PISPIEAVPVTLKPGMDGPRVKQWPLTEEKIKALTEICREMEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAFFSVPL HESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSKYPEIVI CQYVDDLYVASDLEIEQHRTKIEELRAHLLRWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDVIPLTEEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARKKSA HTNDVRQLVDVVQKVITESIVIWGKIPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |