Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3044 | 3044-30306 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V, L90M | L23I, L33F, Q58E, T74P | L10I, I13V, K14KR, L63P, A71V, I93L | G49GE |
| >3044-30306| codons 1-99 PQITLWQRPIVTVRIGGQLKEAILDTGADDTVFEEMNLPGRWKPKLIGEIGGFVKVREYD QIPIEICGHKVIGPVLVGPTPANVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | A62V, V75I | E6K, K122E, I135T, I142V, T200A, R211K, V245K, A272P, I293V, Q334D, I341F, M357MR, G359S, A371V |
| >3044-30306| codons 1-400 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FVIKKKDSTKWRKLIDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGDGQWTYQFYQEPFKNLKTGKYARRRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |