<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3043 3043-30305 France 2003 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184MV, L210W, T215Y K219R K101E, V106M, G190A F227L K20R, V35T, T39A, E44ED, W88S, V118I, K122E, D123DN, I135L, E138A, S162SG, E169D, K173A, Q174K, Q197K, T200A, E203K, Q207D, H208Y, R211K, K223E, V245Q, E248D, A272P, T286A, A288S, E291D, V292I, I293V, E297V, V314X, Q334QE, Q340QH, F346Y, R356K, G359S, I375V, A376S, T377IL, T386I, K390R, Q394L, E399D  
>3043-30305| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICAELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFSEVQLGIPHPAGLEKKKSMTVLDVGDAYFSIPL
DENFRKYTAFTIPSLNNATPGIRYQYNVLPQGWKGSPAIFQGSMTKILDPFRAKNPDIVI
YQYVDDLYVASDLEIGKHRAKIKELRDYLWKWGFYTPDRKHQEEPPLLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKSLTDIVPLTVEAE
LELAENREILKEPXHGVYYDPSKDLIAEIQKQGEGQWTYHIYQEPYKNLKTGKYAKMRSA
HTNDVKQLTEAVQKVSLESIVIWGKIPKFRLPILKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, G48M, I54V, L76V, V82A, L90M K43T, F53L T4S, L10V, K14Q, I15V, G16E, L19I, K20R, E35D, M36V, P39S, K55R, R57K, Q61N, I62V, L63T, H69R, I72V, T74S, L89M, C95CS E65H
>3043-30305| codons 1-99
PQISLWQRPVVTIQVEGQIREALLDTGADDTVLEDVNLSGRWTPKIIMGIGGLVRVKQYD
NVTIHICGRKAVGSVVVGPTPANIIGRNMMTQIGSTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006