Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3043 | 3043-30305 | France | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184MV, L210W, T215Y | K219R | K101E, V106M, G190A | F227L | K20R, V35T, T39A, E44ED, W88S, V118I, K122E, D123DN, I135L, E138A, S162SG, E169D, K173A, Q174K, Q197K, T200A, E203K, Q207D, H208Y, R211K, K223E, V245Q, E248D, A272P, T286A, A288S, E291D, V292I, I293V, E297V, V314X, Q334QE, F346Y, R356K, G359S, I375V, A376S, T377IL, T386I, K390R, Q394L, E399D | Q340QH |
| >3043-30305| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFSEVQLGIPHPAGLEKKKSMTVLDVGDAYFSIPL DENFRKYTAFTIPSLNNATPGIRYQYNVLPQGWKGSPAIFQGSMTKILDPFRAKNPDIVI YQYVDDLYVASDLEIGKHRAKIKELRDYLWKWGFYTPDRKHQEEPPLLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKSLTDIVPLTVEAE LELAENREILKEPXHGVYYDPSKDLIAEIQKQGEGQWTYHIYQEPYKNLKTGKYAKMRSA HTNDVKQLTEAVQKVSLESIVIWGKIPKFRLPILKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48M, I54V, L76V, V82A, L90M | K43T, F53L | T4S, L10V, K14Q, I15V, G16E, L19I, K20R, E35D, M36V, P39S, K55R, R57K, Q61N, I62V, L63T, H69R, I72V, T74S, L89M, C95CS | E65H |
| >3043-30305| codons 1-99 PQISLWQRPVVTIQVEGQIREALLDTGADDTVLEDVNLSGRWTPKIIMGIGGLVRVKQYD NVTIHICGRKAVGSVVVGPTPANIIGRNMMTQIGSTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |