Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3042 | 3042-30305 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K103S | P4T, V35I, K43N, V118I, D123E, D177E, I178M, V189VI, T200A, Q207K, R211D, V245T, A272P, K277R, I293V, R307RK, Q334L, G359S, A371V, A376T, T386M |
| >3042-30305| codons 1-399 PISTIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKSKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYVDDLYIGSDLEIGQHRAKIEELRKHLWDWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE LELAENKEILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKITTESIVIWGKMPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, I84V, L90M | L33F, G48W | W6L, L10I, G16A, E21K, E34K, R41K, Q61D, L63P, A71V, I93L | L38C |
| >3042-30305| codons 1-99 PQITLLQRPIVTIKIAGQLKKALLDTGADDTVFKEMNCPGKWKPKMIWGIGGFVKVRQYD DIPIEICGHKVIGTVLVGPTPANVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |