Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3040 | 3040-30304 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54T, V82A | L24I, L33F, K43T, T74P | L10I, I13V, E34Q, N37S, R41K, I62V, L63P, A71V, V77I |
| >3040-30304| codons 1-99 PQITLWQRPIVTVKIGGQLKEALIDTGADDTVFQEMSLPGKWTPKIIGGIGGFTKVRQYD QVPIEICGHKVIGPVLIGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | N348I | L100I, K103N | E6K, V35VI, T39A, K43E, E44D, A98S, V118I, K122E, D177G, V179I, T200K, R211K, D218E, A272P, I293V, D324E, M357R, R358K, K366R, A371V, I375V |
| >3040-30304| codons 1-399 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEEDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGIKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPGIII YQYVDDLYVGSDLEIGQHRKKIEELRQHLWKWGFYTPEKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKILKTGKYARRKGA HTNDVRQLTEVVQKVATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |