<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3040 3040-30304 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54T, V82A L24I, L33F, K43T, T74P L10I, I13V, E34Q, N37S, R41K, I62V, L63P, A71V, V77I  
>3040-30304| codons 1-99
PQITLWQRPIVTVKIGGQLKEALIDTGADDTVFQEMSLPGKWTPKIIGGIGGFTKVRQYD
QVPIEICGHKVIGPVLIGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y N348I L100I, K103N   E6K, V35VI, T39A, K43E, E44D, A98S, V118I, K122E, D177G, V179I, T200K, R211K, D218E, A272P, I293V, D324E, M357R, R358K, K366R, A371V, I375V  
>3040-30304| codons 1-399
PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEEDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGIKKNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPGIII
YQYVDDLYVGSDLEIGQHRKKIEELRQHLWKWGFYTPEKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKILKTGKYARRKGA
HTNDVRQLTEVVQKVATESIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006