Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3039 | 3039-30304 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K70Q | Y181YC, G190GA | A98G | E40F, K43E, V106I, V118I, D123E, E203A, Q207E, H208Y, R211K, V292I, I293V, R356K, G359S, T386I |
| >3039-30304| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSTQWRKLMDFRELNKRTQDFWEVQLGIPHPGGLKKKKSITVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVASDLEIGQHRTKIAELREYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54L, L76V, I84V, L90M | Q58E, G73S | L10I, I15V, K20T, E34K, E35D, I62V, L63P, A71V, I72L, V77VI, I85V, I93IL |
| >3039-30304| codons 1-99 PQITLWQRPIVTIKVGGQLTEALLDTGADDTVLKDMNLPGRWKPKIIGGIGGFLKVREYD QVPIEICGHKVLSTVVIGPTPVNVVGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |