Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3038 | 3038-30304 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, L210*W, T215F | K219Q | K103S, G190A | K20R, K43N, V60I, K122E, I135M, A158AS, S162Y, T200TA, E203D, L228H, A272P, I293V, S322T, D324E, G335S, G359S, A371V, I375V, A376S, T377I, S379C |
| >3038-30304| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPI FAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKSKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPSIFQYSMTKILEPFRKQNPDIVI YQYMDDLYVASDLEIGQHRAKIDELRQHLWRWGFFTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPTKELIAEIQKQGQSQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKVSIECIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, M46MI, I47V, I54M, I84IV, L90M | L10F, L33I, K43KT, N88ND | K20I, E35D, M36I, N37D, L63P, A71T, I85V |
| >3038-30304| codons 1-99 PQITLWQRPFVTIKIGGQLIEALLDTGADDTIIEDIDLPGRWTPKIVGGIGGFMKVRQYD QIPIEICGHKTIGTVLVGPTPVNVVGRDLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |