Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3037 | 3037-30307 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, L76V, V82F | L23LIM, K43KT, G48GE, F53L | L10I, I15V, G16E, L19LQ, K20M, N37D, D60E, A71V, I72R, I93L |
| >3037-30307| codons 1-99 PQITLWQRPIVTIKVEGQQMEAMLDTGADDTVLEEMDLPGRWTPKIVEGIGGLVKVRQYE QILIEICGHKVRGTVVVGPTPFNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69G_SG, M184I, L210W, T215Y | A62V | Y188L | A98G, V179E | V35I, K64R, D123E, I135T, E138G, S162C, T200A, L228H, V245E, A272P, K277R, E297K, A376S, T377M, K390R |
| >3037-30307| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FVIRKKDSGKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNGTPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIEI YQYIDDLLVGSDLEIGQHRAKIEELRQHLWRWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKISMESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |