Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3036 | 3036-30310 | France | 2003 | HIV1 | CRF02_AG | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V, L90M | L33I, L89V | L10I, T12A, I13A, L19P, K20V, A22V, M36I, R41K, I66F, H69K, K70R, A71V, Q92K |
| >3036-30310| codons 1-99 PQITLWQRPIVAAKIGGQPVEVLLDTGADDTVIEEINLPGKWKPKLIGGIGGFVKVRQYD QILIEFCGKRVIGTVLVGPTPVNVIGRNVMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184I | K219H | Y181C, G190A | A98G, V108I | V35T, E36A, T39K, V60I, V90I, K101R, K122E, D123S, S162A, S163T, T165I, Q174E, D177E, T200A, E203N, Q207K, L210I, D218E, V245Q, K275KQ, K277R, T286A, E291D, I293V, P294T, E297EK, E300EQ, S322T, G335D, R356K, M357K, G359S, A360I, A371V, I375V, K390R, K395R | K46M |
| >3036-30310| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICKEMEKEGMISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEIQLGIPHPGGLRKKKSVTILDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQATMIKILEPFRKENPEIVI CQYIDDLYVASDLEIGQHRAKINELRKHLIRWGFTTPEHKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIQVRQLCKLLRGAKALTDVVTLTKEAQ LELAENREILKEPVHGVYYDPTKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKKRSI HTNDVKQLTEVVQKVATESIVIWGKTPKFRLPIQRETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |