Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3033 | 3033-30227 | France | 2003 | HIV1 | CRF01_AE | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215F | L100I, K103N | V21I, V35T, T39K, K43A, V60I, K173L, Q174K, D177E, T200A, Q207A, R211K, V245Q, L283I, E291D, I293V, E312N, I329V, G335D, F346Y, R356K, M357R, R358G, G359S, T369V, A371V, K390R, E396D |
| >3033-30227| codons 1-399 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALTEICKELEAEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRLKNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELRAHLLKWGFFTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGTKALTDVVPLTEEAE LELAENREILKNPVHGVYYDPSKDLIAEVQKQGQDQWTYQIYQEPYKNLKTGKYAKRGSA HTNDVKQLVEVVQKIATESIVIWGKTPKFRLPIQKDTWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48Q, I50V, I54A, V82M | K43T, F53L | L10I, I13V, G16E, L19R, K20I, E35D, M36I, R41K, Q61D, L63C, I66F, H69K, L89M |
| >3033-30227| codons 1-99 PQITLWQRPIVTVKIEGQRIEALLDTGADDTVLEDINLPGKWTPKMIQGVGGLAKVRQYD DICIEFCGKKAIGTVLVGPTPMNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |