<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3032 3032-30227 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I50V, I54V, V82A, L90M L33F L10I, I13IV, L19I, K20R, E35D, M36I, I62V, L63P, I64M, A71V, I72V, I93L, C95F  
>3032-30227| codons 1-99
PQITLWQRPIVTVKIGGQIREALLDTGADDTVFEDINLPGRWKPKIIGGVGGFVKVRQYD
QVPMEICGHKVVGTVLVGPTPANIIGRNLMTQLGFTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, T215F K219E K103N, Y181C, G190A V108I T69N, V90I, K101R, L109I, K122V, D123N, I135V, I142V, D177E, I178L, D218E, L228R, V245T, Q278E, L283I, I293V, E297A, R307RK, K350R, A355T, R356K, S379SC, K390R  
>3032-30227| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSNRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLRKNKSVTIIDVGDAYFSVPL
DVNFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPELVI
CQYMDDLYVASDLEIGQHRTKIEELRQHLLRWGFFTPEEKHQKEPPFRWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKELCKLIRGTKALTEVVPLTAEAE
LELAENKEILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYTKMRGA
HTNDVKQLTEAVQKIATECIVIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006