<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3029 3029-30319 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, V82A, L90M K43IT L10I, K20R, E35D, M36I, N37D, R41K, K55R, I62IV, L63P, A71T, I72V, I93L  
>3029-30319| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADDTILEDIDLPGKWTPKIVGGIGGFIRVRQYD
QVPIEICGHKTVGTVLVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184V, L210W, T215Y       V35I, T39A, K43E, E44A, K49E, V118I, K122E, D123N, I135T, I142K, T200A, E203Q, Q207D, H208Y, R211K, K223Q, V245E, A288S, E297K, I326V, R356K, M357T, R358K, G359S, A371V, I375V, E399D  
>3029-30319| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEEAGKISEIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DENFRKYTAFTIPSTNNETPGKRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRAKIQELRDYLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLVAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKTKSA
HTNDVKQLTEVVQKVATESIVIWGKTPKFKLPIQKETWDA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006