Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3028 | 3028-30304 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L89LV | L10V, I13M, I15IV, K20I, E34Q, M36I, R41K, L63P, A71V, T74S, I85V, Q92K, I93L |
| >3028-30304| codons 1-99 PQITLWQRPVVTMKVGGQLIEALLDTGADDTVLQEINLPGKWKPKLIGGIGGFVKVRQYD QIPIEICGHKVIGSVLVGPTPANIVGRNVMTKLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | K103N, Y188L | K43KE, S105T, V179T, T200A, Q207E, R211K, F214L, K223KE, E224D, I244IV, V245T, T286A, M357T, K390R |
| >3028-30304| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKTVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDITI YQYVDDLLVGSDLEIGQHRAKIEELREHLWKWGLYTPDKKHQEDPPFLWMGYELHPDKWT VQPVTLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |