Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3027 | 3027-30304 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | Y188L | K20KR, T39S, K43N, K49R, V60VI, D123E, I135IT, T139TIM, S162C, T165V, D177E, V179VI, G196E, T200A, Q207E, R211K, V245E, K277KR, T286A, A288S, V292I, E297K, K311R, G333GE, Q334D, G335S, R356K, V365VI, K388KT, K390R |
| >3027-30304| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICSELENEGKISRIGPENPYNTPI FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNEMPGIRYQYNVLPQGWKGSPAIFQCSMVKILEPFRKQNPEIII YQYMDDLLVGSDLEIEQHRAKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKSLTEIIPLTKEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQEDSQWTYQIYQEPFKNLKTGKYAKMRGA HTNDIKQLTEAVQKIATESIVIWGKTPTFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54S, V82A | L33F, Q58E | L10I, T12I, I13IV, G16E, I62V, L63H, A71V, V77I, I93L |
| >3027-30304| codons 1-99 PQITLWQRPIVIVKIEGQLKEALLDTGADDTVFEEMNLPGRWKPKLIVGIGGFSKVREYD QVHIEICGHKVIGTVLIGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |