Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3026 | 3026-30303 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, V75T, T215Y | K219R | V108I, F227L | K43Q, V118I, K122E, S162A, I178M, V179I, T200A, E203K, H208FY, L210Y, R211Q, K223E, L228R, Q242L, S251H, A272P, V292I, I293V, S322T, P345T, M357T, G359S, V365I, T369V, T377TI, K390R |
| >3026-30303| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPV FAIKKKDSTKWRKITDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDMII YQYMDDLYVGSDLEIGQHRAKIKELRQYLYQWGFYTPDRKHQEEPPLRWMGYELHPDKWT VLPIVLPEKDHWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIVPLTEEAE LELAENREILKEPVHGVYYDPTKDLIAEIQKQGQGQWTYQIYQETFKNLKTGKYARTRSA HTNDIKQLVEAVQKIAIESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, V82A, L90M | L33F, F53L, G73C | L10I, I13V, E34Q, N37S, K55R, L63P, I93L, C95F |
| >3026-30303| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTIFQEMSLPGRWKPKIVGGIGGLLRVRQYD QIPIEICGHKAICTVLVGPTPANIIGRNLMTQLGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |