Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3025 | 3025-30324 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, L74LI, L210W, T215Y | K219N | K103N | A98G, V108I, F227L | K20R, K43N, W88WC, K122E, E138G, E203K, H208Y, R211K, K223E, L228H, A272P, L283I, S322T, G359S, K366R, A376S, S379C, V381I, K390R |
| >3025-30324| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKRTQDFCEVQLGIPHPGGLKKNKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSINNGTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIKELRQYLWKWGFYTPDNKHQEEPPLHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPTKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVRQLTEAVQKISTECIIIWGKTPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, L76V, V82A | L24I, L33F, K43T | L10I, I13V, G16GA, K20R, E35D, M36I, N37S, R57RK, I62V, L63P, T74TA, L89IM |
| >3025-30324| codons 1-99 PQITLWQRPIVTVKIAGQLREALIDTGADDTVFEDISLPGRWTPKLIGGIGGFVKVKQYD QVPIEICGHKAIGAVVVGPTPANIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |