<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3025 3025-30324 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, L76V, V82A L24I, L33F, K43T L10I, I13V, G16GA, K20R, E35D, M36I, N37S, R57RK, I62V, L63P, T74TA, L89IM  
>3025-30324| codons 1-99
PQITLWQRPIVTVKIAGQLREALIDTGADDTVFEDISLPGRWTPKLIGGIGGFVKVKQYD
QVPIEICGHKAIGAVVVGPTPANIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67DN, L74LI, L210W, T215Y K219N K103N A98G, V108I, F227L K20R, K43N, W88WC, K122E, E138G, E203K, H208Y, R211K, K223E, L228H, A272P, L283I, S322T, G359S, K366R, A376S, S379C, V381I, K390R  
>3025-30324| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV
FAIKKKNSTKWRKIVDFRELNKRTQDFCEVQLGIPHPGGLKKNKSVTILDVGDAYFSVPL
DEDFRKYTAFTIPSINNGTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIKELRQYLWKWGFYTPDNKHQEEPPLHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPTKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVRQLTEAVQKISTECIIIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006