Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3024 | 3024-40430 | France | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 61 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, L210W, T215Y | F77L, K219N | K101P, K103N | E6D, T39A, K43E, E44A, V106I, V118I, K122E, K223Q, L228H, Q242H, K277R, T286A, I293V, V317A, M357T, K395R, E399D | K390GR |
| >3024-40430| codons 1-399 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKLMDLRELNKRTQDFWEVQLGIPHPAGLPKNKSITVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFYTPDNKHQQEPPFHWMGYELHPDKWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVVPLTEEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQRETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M, I84V, L90M | G73A, L89V | L10I, I13A, Q18H, K20I, E35EG, M36I, N37D, L63P, I64V, I66F, A71T, I72IL |
| >3024-40430| codons 1-99 PQITLWQRPIVTAKIGGHLIEALLDTGADDTVLEGIDLPGRWKPKIVGGIGGFMKVRQYD QIPVEFCGHKTLATVLVGPTPVNVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |