Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3023 | 3023-30303 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219Q | K103N, Y181C | V35I, V60I, D123E, I135V, R172K, D177E, G196E, I202V, H221Y, L228H, A272P, I293V, S322T, Q334N, G335GS, T338S, T369V, A371AT, I375V, E399D |
| >3023-30303| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPEIVI CQYMDDLYVGSDLEIEQHRTKVEELRQHLLRWGFFTPDQKYQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPTKDLIAEIQKQGNSQWSYQIYQEPFKNLKTGKYARMRGA HTNDVKQLVETVQKVATESIVIWGKTPKFKLPIQKETWDA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82C, I84V, L90M | F53L, T74P | L10I, R41K, I62V, L63P, I64V, A71V, V77I, I93L |
| >3023-30303| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGLIKVRQYD QVPVEICGHKVIGPVLIGPTPCNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |