Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3022 | 3022-30313 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74I, V75T, M184V, T215F | K219Q | K103N, Y181C, G190A | A98G, V108I | K20KR, V35L, L109LI, V118I, K122P, I135T, D177E, G196E, I202V, F214L, H221Y, L228LH, A272P, K277R, Q278H, L283I, I293V, Q334H, K350R, G359S, A371V, I375V, A376T, E399D |
| >3022-30313| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTELEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKITDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTIIDVGDAYFSIPL DPDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYVDDLYVASDLEIEQHRTKVEELRQHLLRWGLFTPDQKYQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRHLCKLIRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHGQWTYQIYQEPFKNLRTGKYARMRSA HTNDVKQLTEVVQKVTTESIVIWGKTPKFKLPIQKETWDA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54A, V82F, L90M | L33LF | L10I, L19I, E34Q, N37D, D60E, I62IV, L63P, I64LV, A71V, V77I, Q92K, I93M |
| >3022-30313| codons 1-99 PQITLWQRPIVTIKIGGQIKEALLDTGADDTVFQEMDLPGRWKPKMIGGIGGFAKVRQYE QVPVEICGHKVIGTVLIGPTPFNIIGRNLMTKMGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |