<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3022 3022-30313 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54A, V82F, L90M L33LF L10I, L19I, E34Q, N37D, D60E, I62IV, L63P, I64LV, A71V, V77I, Q92K, I93M  
>3022-30313| codons 1-99
PQITLWQRPIVTIKIGGQIKEALLDTGADDTVFQEMDLPGRWKPKMIGGIGGFAKVRQYE
QVPVEICGHKVIGTVLIGPTPFNIIGRNLMTKMGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, K70R, L74I, M184V, T215F V75T, K219Q K103N, Y181C, G190A A98G, V108I K20KR, V35L, L109LI, V118I, K122P, I135T, D177E, G196E, I202V, F214L, H221Y, L228LH, A272P, K277R, Q278H, L283I, I293V, Q334H, K350R, G359S, A371V, I375V, A376T, E399D  
>3022-30313| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSDRWRKITDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTIIDVGDAYFSIPL
DPDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
CQYVDDLYVASDLEIEQHRTKVEELRQHLLRWGLFTPDQKYQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRHLCKLIRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHGQWTYQIYQEPFKNLRTGKYARMRSA
HTNDVKQLTEVVQKVTTESIVIWGKTPKFKLPIQKETWDA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006