Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3021 | 3021-30313 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, L210W, T215Y | K219R | K101E, Y181C, G190A | T39A, E44D, V111I, V118I, K122E, I135T, E203K, H208Y, R211Q, K223Q, V245T, K277R, Q278E, T286A, E297R, N348T, R356K, T362S, E370D, K385KR, T386TI, K390R |
| >3021-30313| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDIGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVASDLEIGQHRTKIKELRQYLWQWGFYTPDRKHQQEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRELCKLLRGAKALTEVIPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKTLKTGKYAKMRGA HSNDVKQLTDAVQKIATESIVIWGRIPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82A, L90M | L10FV, K43T, G73S, L89V | I13IV, I15V, G16GA, M36MATV, I62IV, L63P, A71V, I72IL |
| >3021-30313| codons 1-99 PQITLWQRPVVTVKVAGQLKEALLDTGADDTILEEVNLPGRWTPKIVGGIGGFMKVRQYD QVPIEICGHKVLSTVLVGPTPANIIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |