<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3020 3020-30303 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54L, L76V, L90M L10F, L23I, L33F, Q58E, G73S, L89V I13V, E34Q, E35D, M36I, K55R, R57K, I62V, L63P, A71V, I72L K20A
>3020-30303| codons 1-99
PQITLWQRPFVTVKIGGQLAEAILDTGADDTVFQDINLPGRWKPKIIGGIGGFLRVKEYD
QVPIEICGHKVLSTVVVGPTPVNIIGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, V75M, M184V, L210W, T215Y K219E   A98AG K20R, V35VA, E44ED, V60I, T69TP, V118VI, K122E, I142IV, G196E, E203K, Q207DE, H208Y, R211K, L228H, T286A, I326V, Q334QL, F346Y, A355AG, R358K, G359S, V365I, A371T, T377L, K390R, E399D  
>3020-30303| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALAEICTELEKDGKISKIGPENPYNTPI
FAIKKKNSPRWRKLMDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIEQHRTKIKELREYLWKWGFYTPDEKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLVAEIQKQGLGQWTYQIYQEPYKNLKTGKYGRMKSA
HTNDIKQLTETVQKIALESIVIWGKTPKFRLPIQKETWDA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006