Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3019 | 3019-30812 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70GR, L74V, M184I, L210W, T215Y | K219Q | L100I, K103S | A98G | V35IT, K43N, V118I, D123E, I135T, T200A, E203K, H208Y, R211Q, D218E, K223Q, L228H, Q242H, D250E, A272P, T286A, E297K, S322T, I329IV, K350R, G359S, A371V |
| >3019-30812| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELENEGKISKIGPENPYNTPV FAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHPGGIKKSKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYIDDLYVGSDLEIGQHRAKIKELRQYLWQWGFYTPEQKHQQEPPFHWMGYELHPDKWT VHPIVLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPTKDLIAEVQKQGQGQWTYQIYQEPFKNLRTGKYARMRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10F, L33I, Q58E, L89V | T4PS, V11L, I13V, L19LV, K20I, E35D, M36I, L63P, A71V, I93L | T91TCS |
| >3019-30812| codons 1-99 PQISLWQRPFLTVKIGGQVIEALLDTGADDTVIEDINLPGRWKPKLIGGIGGFVKVREYD QIPIEICGHKVIGTVLVGPTPANIIGRNVMSQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |