Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3016 | 3016-30408 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, L74I, M184V, T215F | K219Q | L100I, K103N | V108I | P4S, E6D, K20R, V35L, V60I, V118I, D123E, I135V, Q174K, D177E, V179T, I202V, R211K, F214L, H221Y, V245M, I293V, E297R, V317A, Q334E, E344D, F346Y, R356RK, G359S, S379SC, K390R, E399D |
| >3016-30408| codons 1-399 PISSIDTVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTILDVGDAYFSIPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPEITI YQYVDDLYVGSDLEIGQHRTKVEELRQHLLKWGLFTPDQKYQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTREAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGEGQWTYQIYQDPYKNLKTGKYAKMRSA HTNDVKQLTEAVQKIATECIVIWGKTPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, I84V, L90M | Q58E | L10I, L19I, K20R, E35D, M36I, N37D, I62V, L63P, A71L, I85V, T91S, I93L |
| >3016-30408| codons 1-99 PQITLWQRPIVTIKIGGQIREALLDTGADDTVLEDIDLPGRWKPKMIGGIGGFVKVREYD QVPIEICGHKLIGTVLVGPTPANVVGRNLMSQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |