<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3016 3016-30408 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, L74I, M184V, T215F K219Q L100I, K103N V108I P4S, E6D, K20R, V35L, V60I, V118I, D123E, I135V, Q174K, D177E, V179T, I202V, R211K, F214L, H221Y, V245M, I293V, E297R, V317A, Q334E, E344D, F346Y, R356RK, G359S, S379SC, K390R, E399D  
>3016-30408| codons 1-399
PISSIDTVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTILDVGDAYFSIPL
DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPEITI
YQYVDDLYVGSDLEIGQHRTKVEELRQHLLKWGLFTPDQKYQKEPPFLWMGYELHPDKWT
VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTREAE
LELAENREILKEPVHGAYYDPSKDLIAEIQKQGEGQWTYQIYQDPYKNLKTGKYAKMRSA
HTNDVKQLTEAVQKIATECIVIWGKTPKFRLPIQKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A, I84V, L90M Q58E L10I, L19I, K20R, E35D, M36I, N37D, I62V, L63P, A71L, I85V, T91S, I93L  
>3016-30408| codons 1-99
PQITLWQRPIVTIKIGGQIREALLDTGADDTVLEDIDLPGRWKPKMIGGIGGFVKVREYD
QVPIEICGHKLIGTVLVGPTPANVVGRNLMSQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006