Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3014 | 3014-30331 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KNRS, L74LV, V75VIM, M184V, T215F | K219Q | K103N | A98G, K238T | E6EK, T39A, V60I, V118I, K122E, I135T, I142V, S162Y, Q207E, L228HR, V245T, K275Q, K277R, P294T, E297K, I329L, R356K, M357K, G359S, T369A |
| >3014-30331| codons 1-399 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPI FAIKKKNSTSWRKVMDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGFFTPDQKHQKEPPFRWMGYELHPDTWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIQVRQLCKLLRGTKALTEVITLTKEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYAKKRSA HTNDVKQLAEAVQKIATESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, L90M | L10F, L33F | L63P, A71V, V77I, I93L |
| >3014-30331| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKIIGGVGGFIKVRQYD QIPIEICGHKVIGTVLIGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |