Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3012 | 3012-30305 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82A, L90M | L10F, K43T, F53LW | M36A, P39T, I62V, L63P, I64V, A71IV, V77VI, L89M, I93L |
| >3012-30305| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTILEEANLTGRWTPKIVGGIGGWMKVRQYD QVPVEICGHKVIGTVLIGPTPANIIGRNMMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, L210W, T215Y | K219N | Y181YC, Y188L | V35M, T39A, E40F, K43E, V118I, K122P, I135T, T139AV, D177E, I178V, I195L, G196E, H208Y, V245VE, V276T, L283I, I293V, E297R, R356K, G359S, A360T, K390R |
| >3012-30305| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAFLEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DPDFRKYTAFTIPSTNNEVPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEVVI CQYMDDLLVGSDLELEQHRTKIEELRQYLWRWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKTKQLCKLIRGTKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRST HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |