<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3012 3012-30305 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54M, V82A, L90M L10F, K43T, F53LW M36A, P39T, I62V, L63P, I64V, A71IV, V77VI, L89M, I93L  
>3012-30305| codons 1-99
PQITLWQRPFVTIKIGGQLKEALLDTGADDTILEEANLTGRWTPKIVGGIGGWMKVRQYD
QVPVEICGHKVIGTVLIGPTPANIIGRNMMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, L210W, T215Y K219N Y181YC, Y188L   V35M, T39A, E40F, K43E, V118I, K122P, I135T, T139AV, D177E, I178V, I195L, G196E, H208Y, V245VE, V276T, L283I, I293V, E297R, R356K, G359S, A360T, K390R  
>3012-30305| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAFLEEEGKISKIGPENPYNTPV
FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DPDFRKYTAFTIPSTNNEVPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEVVI
CQYMDDLLVGSDLELEQHRTKIEELRQYLWRWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKTKQLCKLIRGTKALTEVVPLTREAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRST
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006